What Is NAD Supplementation?

NAD supplementation is the use of products that help increase levels of NAD+ (Nicotinamide Adenine Dinucleotide) in the body. NAD+ is a natural molecule found in all human cells, and it plays a vital role in energy production, cell repair, brain function, and healthy ageing. As we get older, our NAD+ levels naturally decline. Supplementing with NAD+ or its precursors may help support energy, focus, and overall wellbeing.

Why do people take NAD supplements?

People take NAD supplements to help:

Boost energy levels and reduce tiredness
Support mental clarity and focus
Promote healthy ageing and longevity
Support muscle recovery and performance
Enhance overall cell health and DNA repair

NAD supplementation is especially popular among those interested in biohacking, wellness, and age-related health support.

What types of NAD supplements are available?

Most supplements don’t contain NAD+ itself but rather its precursors – ingredients that the body uses to make NAD+. These include:

NR (Nicotinamide Riboside) – a widely used NAD+ precursor found in many supplements
NMN (Nicotinamide Mononucleotide) – another popular and well-researched precursor
Nicotinamide – a form of vitamin B3 that the body can convert to NAD+

These supplements are usually taken in capsule or tablet form, though some are available as powders, drinks, or under-the-tongue formulas for faster absorption [1][2].

What about NAD+ injections or infusions?

In clinical or wellness settings, NAD+ can also be given directly through an intravenous (IV) infusion or subcutaneous injection. This allows it to bypass the digestive system and enter the bloodstream more quickly. These methods are usually offered by trained medical professionals and may be used for:

Fatigue and burnout recovery
Cognitive enhancement
Anti-ageing support
High-performance recovery (e.g. athletes or shift workers)

Is NAD supplementation safe?

Most NAD+ supplements and precursors are considered safe when used as directed [3]. Side effects are rare but can include mild digestive upset in some people. Injections and infusions should always be given by qualified professionals using regulated products. As with any supplement, it’s best to speak to a healthcare provider before starting – especially if you’re pregnant, breastfeeding, or have a medical condition.

Who might benefit from NAD supplementation?

NAD+ supplements may be helpful for:

People over 30 who want to support healthy ageing
Those with low energy or mental fatigue
Professionals or students needing improved focus
People recovering from stress or illness
Athletes and active individuals supporting muscle recovery

Key Takeaways

NAD supplementation helps increase NAD+ levels, which support energy, brain function, and cell repair.
Most supplements contain precursors like NR or NMN that the body converts to NAD+.
NAD+ can also be delivered by injection or IV for faster absorption under professional care.
It may support healthy ageing, mental clarity, and overall vitality, especially as we get older.
Always speak to a healthcare provider before starting new supplements or treatments.

Reminder: NAD supplementation is part of a wider approach to wellbeing. A balanced diet, regular exercise, good sleep, and hydration are also important for energy, ageing, and long-term health.

Sources

[1] Freeberg KA, Udovich CC, Martens CR, Seals DR, Craighead DH. Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions. J Gerontol A Biol Sci Med Sci. 2023 Dec 1;78(12):2435-2448. doi: 10.1093/gerona/glad106. PMID: 37068054; PMCID: PMC10692436.

[2] Henderson, J.D., Quigley, S.N.Z., Chachra, S.S. et al. The use of a systems approach to increase NAD+ in human participants. npj Aging 10, 7 (2024). https://doi.org/10.1038/s41514-023-00134-0

[3] Gindri IM, Ferrari G, Pinto LPS, Bicca J, Dos Santos IK, Dallacosta D, Roesler CRM. Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review. Am J Physiol Endocrinol Metab. 2024 Apr 1;326(4):E417-E427. doi: 10.1152/ajpendo.00242.2023. Epub 2023 Nov 16. PMID: 37971292.