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What is Evorel Sequi?
Evorel Sequi is a Hormone Replacement Therapy (HRT), used to treat women who have started to show signs of the menopause.
How does Evorel Sequi work?
During a woman’s menopause, natural levels of oestrogen production begin to drop. Evorel Sequi is known as ‘continuous sequential’ HRT, as it contains the female hormones, oestrogen and progestogen, released on a sequence. First, oestrogen is released on its own for two weeks, and then it's released together with progestogen for two weeks. These hormones work to replenish a woman’s natural levels and offset the effects of menopause.
What are the benefits of using Evorel Sequi?
Symptoms of menopause include hot flashes (of the face, neck and chest), irregular menstrual cycle, night sweats, weight gain, thinning of hair and mood changes.
These symptoms can often disrupt daily life so using HRT medication, such as Evorel Sequi, can restore the natural hormone balance.
How do I use Evorel Sequi?
Evorel Sequi is a prescription-only medication. Always follow the advice of your doctor and read the patient information leaflet provided in the medication packet. Evorel Sequi comes in a variety of doses and your doctor will aim to prescribe you the lowest one possible to help with your symptoms.
Evorel Sequi comes as an adhesive patch which should be worn continuously until it’s time to replace it with a new one. Your Evorel Sequi patch should be replaced twice weekly (every 3 to 4 days), which is generally best to do on the same two days of each week (like Monday and Thursday). These must be done in the correct order; the four Evorel 50 patches (oestrogen only) one at a time for the first two weeks, and then the four Evorel Conti patches (combined hormone) for the next two weeks. The patches should be replaced one after another with no patch-free days.
If you are no longer having periods, nor using any form of HRT, you can start to use Evorel Sequi on any convenient day. If you are still having periods but using no HRT treatment, then apply your first patch on the first day of your next period. If you are changing from another HRT treatment, you should start to use Evorel Sequi on the day after you complete your previous cycle.
To apply the patch, make sure your skin is clean and dry and remove the protective backing to reveal the sticky side. Keeping your fingers away from the sticky side, apply the patch to the skin on the lower abdomen, thigh or bottom and press gently for about 10 seconds. Avoid the waistline area as this can be rubbed by clothes, and never apply the patch to your breasts or the area near them. Each time you change your patch, try to change the spot slightly so that the skin does not become irritated.
The patches are designed to withstand normal activities like exercising, showering and bathing so you shouldn’t have to worry about it. However, do make sure to check it after these activities to ensure it’s still in place.
You may have some light or spotted bleeding in the first few weeks, however if it’s heavy or persistent then you should contact your doctor.
Evorel Sequi dosage
Evorel Sequi packets contain half of the Evorel 50 patches and half of the Evorel Conti patches. The Evorel 50 patches contain 3.2 mg of estradiol, corresponding to a release of 50 micrograms per 24 hours. The Evorel Conti patches contain 3.2 mg of estradiol (corresponding to a release of 50 micrograms per 24 hours), and 11.2 mg of norethisterone acetate (corresponding to a release of 170 micrograms per 24 hours).
If you use too much Evorel Sequi then remove the patch. This is unlikely due to the way in which it’s used but if you do, then symptoms could include tenderness of the breasts and/or vaginal bleeding. If symptoms persist contact your doctor.
If you forget to change the patch, do it as soon as you remember. No matter what day this happens, go back to changing the newly applied patch on the same days as your original schedule. Never double up on a dose to make up for a forgotten one.
Side effects & precautions
Before using Evorel Sequi, you should always first consult your doctor. You should not use Evorel Sequi if any of the following apply to you:
- If you have ever had breast cancer or are suspected of having it
- If you have cancer that is sensitive to oestrogens
- If you have any unexplained vaginal bleeding
- If you have excessive thickening of the womb lining
- If you have or have ever had a blood clot in a vein
- If you have a blood clotting disorder
- If you have ever had a disease caused by blood clotting in the arteries
- If you have ever had a liver disease
- If you have a rare blood problem called porphyria
- If you are allergic to any of the ingredients in this medication
Your prescription of Evorel Sequi may also be affected by a number of other factors, so you should make your doctor aware if any of the following apply:
- If you’ve ever had fibroids inside the womb
- If you’ve ever had growth of the womb lining outside of your womb
- If you have an increased risk of developing blood clots
- If you have an increased risk of oestrogen-sensitive cancer
- If you have high blood pressure
- If you have a liver disorder
- If you have diabetes
- If you have gallstones
- If you suffer with migraines or severe headaches
- If you have a disease of the immune system that affects many organs
- If you have epilepsy
- If you have asthma
- If you have a disease affecting the eardrum and hearing
- If you have a very high level of fat in your blood
- If you have fluid retention due to cardiac or kidney problems
Like many medications with active ingredients, Evorel Sequi can affect or be affected by other medicines. Particular medications that you may experience this with include the following:
- Medicines for epilepsy
- Medicines for tuberculosis
- Medicines for HIV infection
- Herbal remedies contains St John’s Wort
- Other anti-infective medicines
If you are taking any of the above medications, then you should make your doctor aware so that they can advise whether or not Evorel Sequi will be the best course of action for you.
Taking HRT medication can increase your chances of excessive thickening of the lining of the womb, cancer of the womb lining, and breast cancer so be sure to pay attention to your body, inspect your breasts regularly and notify your doctor of any changes you notice.
Blood clots are higher in HRT users than in non-users, especially during the first year of taking it. Again, you should keep an eye out for any possible signs of a blood clot and contact your doctor if you notice anything different.
The most common side effects of using Evorel Sequi include:
- Irritation of the skin where the patch is applied
- Breast pain
- Rash or feeling itchy
- Feeling dizzy, headache
- Feeling depressed or mood change
- Feeling sick or having stomach pains, diarrhoea
- Breakthrough bleeding, spotting or periods
- Weight gain
If you do experience one or more of these side effects and they persist or worsen, then inform your doctor right away. You should also contact your doctor immediately if you experience any serious side effects.
How do I buy Evorel Sequi online?
You can safely buy Evorel Sequi online at UK Meds. You will first need to have an online consultation with a pharmacist independent prescriber before your order will be supplied. The online consultation will ensure that Evorel Sequi is the right medication for your medical condition.