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Amitriptyline is a medicine used to treat neuropathic pain.

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Neuropathic Pain

UK Meds asked our favorite doctor, Dr. Christian Jessen, to explain Neuropathic Pain. Below is what he has to say.

Neuropathic pain is a complex chronic state of pain that can be the result of tissue injury or a malfunctioning nervous system where nerve fibers may be damaged, dysfunctional or injured. Neuropathic pain can be difficult to treat as damaged nerves can send confusing signals to the brain. An injury which should only produce mild pain can be perceived as excruciating, stabbing, shooting, burning or even like an electric shock.

Neuropathic pain can also sometimes be felt when there's no apparent reason or cause of pain at all. If you've been diagnosed with neuropathic pain, there are several medications which could provide relief, including amitryptaline, pregabalin and duloxetine. People in pain need access to effective medication. UK Meds can prescribe these for you and (most importantly), get them to you quickly.

- Dr. Christian Jessen

The video and article above is for information purposes only. They are not intended to diagnose a condition or prescribe a medicine. If you have any specific concerns about your health, please consult your GP or use our online doctor's service. You can follow Dr. Christian Jessen online on his Twitter account.

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What is Amitriptyline?

Amitriptyline is a kind of tricyclic antidepressants. It impacts the brain by altering the balance of the natural chemicals called serotonin, a type of neurotransmitters.

It is the newest paradigm when it comes to treating nerves or neuropathic because it shows promising results and it is now considered as the most effective drug to treat this ailment. It is also an effective treatment for chronic discomfort which is from spinal problems, chronic headaches, arthritis, fibromyalgia and tension headaches.

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Amitriptyline's primary use is to treat alleviate pain, calm the muscles and enhance discomfort that deals with insomnia. Aside from that, it can also lower depression and anxiety of a patient. This medicine works by altering the process of the spine when sending messages. When a certain nerve is destroyed, it becomes infuriated, and it fails to send the appropriate details.

Chronic pain can be identified because of the changes it contributes to the central nervous system, specifically the spinal cord. It then develops into insufficient pain regulation. It is called amplification or wind-up, and it increases the stress brought by this. It helps by balancing the chemicals known as neurotransmitters which also help normalise and decrease the amount of defected messages sent by the nerves. As a result, the patient will feel less discomfort. The inappropriate messages sent to the brain also impact the mood and sleeping pattern of the patient. Amitriptyline works by enriching the sleeping pattern.

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Treatment for Neuropathic Pain

Neuropathic pain comes from damaged nerves, and can have a variety of different names. Some of the more common are painful diabetic neuropathy, postherpetic neuralgia, or post-stroke. It is different from messages that are carried along healthy nerves from damaged tissue (for example, a fall, or cut, or arthritic knee). Neuropathic pain is treated by different medicines to those used for damaged tissue. Medicines such as paracetamol or ibuprofen are not usually effective in neuropathic pain, while medicines that are sometimes used to treat depression or epilepsy can be very effective in some people with neuropathic pain.

Amitriptyline Antidepressant

Amitriptyline is an antidepressant, and antidepressants are widely recommended for treating neuropathic pain. Amitriptyline is commonly used to treat neuropathic pain conditions, but an earlier review found no good quality evidence to support its use. Most studies were small, relatively old, and used methods or reported results that we now recognise as making benefits seem better than they are.

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Sold under the brand Elavil (among others), it has been prescribed to treat arthritis, back and neck pain as well as Fibromyalgia. It can help chronic tension headaches and ease discomfort from damage to nerve endings in outer extremity limbs. It should not be sold to anyone who has a condition called "heart block", uncontrolled bipolar mood swings, acute porphyria (an enzyme disorder causing nerve problems), or some types of glaucoma. Your doctor can help you decide which medical conditions would be best suited for treatment with this drug."