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Tretinoin is an incredibly effective treatment for acne and sun-damaged skin. Tretinoin 0.05% cream can also help the skin to appear smoother by helping the appearance of surface wrinkles. Tretinoin helps the skin to remove damaged cells and replace them with fresh, healthy new ones.

Tretinoin usage can make your skin more sensitive to sunlight, so using a high-SPF (SPF30) moisturiser such as Purifide, is vital for staying protected.

Please note: Tretinoin is dispensed from an EU pharmacy. You may receive a branded version of the medication called 'Ketrel'.

  • Effectively treats acne
  • Helps the appearance of fine lines and wrinkles
  • Viral TikTok skincare treatment
  • Shipped from EU Pharmacies
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Tretinoin Cream UK

Tretinoin is a topical skincare medication that is used to help rejuvenate skin cells. It is an incredibly effective treatment that has become increasingly well-known and popular due to its excellent results.

Video: A Guide to Tretinoin

UK Meds have created a video guide to explain what Tretinoin is. Watch it below:


What is Tretinoin? @uk.meds #MedsTok #tretinoin #acne #tretinointreatment

♬ original sound - UK.Meds


Tretinoin is also available under the brand name Ketrel (0.05%). You may receive tretinoin in the form of Ketrel cream at UK Meds.

Tretinoin is used to help treat acne and damaged skin. These can be cells that have been damaged by the sun or skin cells that appear as dark spots. As well as this, Tretinoin can also be used to help the appearance of surface wrinkles and fine lines on the skin. Tretinoin will leave users with fresher, smoother skin.

Tretinoin is a synthetic version of vitamin A. It irritates the skin to the point where it speeds up the life cycle of skin cells. It makes a skin cell divide faster and die quicker, speeding up the process of you getting fresh, new skin cells. These new skin cells are healthier and will reduce the appearance of acne and wrinkles. Tretinoin also stimulates collagen and elastin in the skin which leads to a smoother-looking surface.

Google Web Story: What to Expect When Taking Tretinoin?

UK Meds created the below Google Web Story to explain what to expect when using Tretinoin cream:

It is important to note that people may have different experiences when they use Tretinoin. If someone states that their medication did not work as they had hoped, it does not mean that it will not work for you. If you believe that Tretinoin is the right medication for you then the best thing to do is give it a try, get through the purge phase, and judge the medication based on your own experiences. Reviews however should not be understated. Reading reviews can provide you with important advice and information that you may not have known, and can inform you on whether or not to start using Tretinoin. If you are unsure about starting a medication you should always consult with your healthcare provider first.

Check out some independent tretinoin user reviews and tretinoin user experiences below.

Tretinoin User Experience 1Tretinoin User Experience 2Tretinoin User Experience 3Tretinoin User Experience 4Tretinoin User Experience 5Tretinoin User Experience 6Tretinoin User Experience 7
@_vegetarianna 8 week tret update!! #tretinoin #acne #AerieREAL #acnejourney #accutane #tretinoinjourney ♬ Moments / Tides - Goth Babe
@diaryofirma A lil tretinoin transformation for the clock app #tretinoin #beforeandafter ♬ Peace - Official Sound Studio
@___x4mbx My skin journey I started on 0.25 Tretinoin now using 0.1 Tretinoin #skincare #skin #tretinoin #skincarebyhyram #dermatologist ♬ Intimidated - KAYTRANADA
@angel_stykemain A before and after comparison with tretinoin use. Amazing how my skin has improved a lot! I am so happy I did it and never gave up during the ugly and purging phase. It is all worth it! #50yearsyoung #aginggracefully #agingwell #tretinoin #tretinoinbeforeandafter #tretinoinresults #tretinoincream #fyp #foryou #foryoupage ♬ As It Was - PREP
@fresh_faced_skincare A long journey but a good one #tretinoin #skincare #skincareroutine #acne #koreanskincare #barrierrepair #hydration #adultacne #skincarejourney #beforeandafter ♬ Why Are There Boundaries - FKJ
@abbeyyung ok those results still freak me out a little #tretinoinjourney #tretinoin #skincarejourney #skincareglowup #skincaretransformation #tretinoinbeforeandafter ♬ FOLLOW ME MIKUULSTANCE - Mikuulstance
@aesthetician.emily my Tretinoin journey #tretinoin #acne ♬ New Person, Same Old Mistakes - Tame Impala

Tretinoin Reviews

Here are some real reviews from genuine users of Tretinoin.

“This is the best my face has been in more than a decade. I'd highly recommend.”

"I have to say the skin that's left looks amazing-so smooth.”

To read more reviews from Tretinoin users, please check out

Tretinoin Cream

Tretinoin is simple to use. Firstly, you should ensure that your face is clean and that you are not wearing any makeup. If your skin is already sensitive then you should do this gently. Let your face dry before applying Tretinoin cream. Here are some easy-to-follow steps for applying Tretinoin cream correctly:

  1. Apply once daily, generally before bed.
  2. Put about half an inch of cream onto your fingertips.
  3. Gently rub the cream into the areas of the face that need it most.
  4. If the cream does not fade away instantly you should rub it in and try to apply a little less in the future.
  5. Avoid using large amounts of the cream as this could irritate the skin further.

The amount of time that you use Tretinoin will vary from person to person. In general, it is recommended that people use Tretinoin for up to six months so that they can get through the initial ‘purge’ phase. After four months you should be able to notice a distinct improvement in your skin. After that, you can discuss how long you would like to use the treatment for. Some people even use Tretinoin as part of their ongoing skincare routine.

Tretinoin 0.05% Cream

Apply Tretinoin cream to the affected area(s) of your skin once a day, preferably at bedtime as directed by your doctor. Your dose may differ from the average doses and you should not change it unless instructed by your healthcare provider. At UK Meds, Tretinoin cream is available in a strength of 0.05%.

As with all prescription medications, there is a chance that you may experience some side effects when you use Tretinoin. Here are some of the more common side effects of Tretinoin:

  1. A skin ‘purge’ for the first few months, which may mean your skin appears worse before it gets better
  2. Redness
  3. Peeling of the skin
  4. Itching/burning

These side effects are all to be expected when you first start using the medication and it is important that you stick with the treatment as positive results are usually expected around 3-4 months after you start using Tretinoin.

Potential side effects of Tretinoin

Description of side effect

Skin PurgeMay appear worse for first few months before it gets better
RednessSkin may become red when using Tretinoin
PeelingSkin may peel when using Tretinoin
Itching/BurningUsers may experience itching and burning sensations when applying the cream.

Tretinoin has become an increasingly popular treatment for a number of different conditions. It can provide users with many different benefits including the opening and unclogging of pores, the clearance of stubborn and chronic acne, the general improvement of wrinkles and skin texture, and the reduction of new acne forming. The benefits of Tretinoin will far outweigh the drawbacks. Once you have got through the initial ‘purge’ phase you will begin to experience the benefits.

When you initially start to use Tretinoin you may not experience any effects for a couple of weeks. Usually, after this time users will begin to enter a so-called ‘purge’ phase. This is where the skin may seem to worsen, peel, redden, and become irritated. It is important to note that this is normal and that you should persist with your treatment as normal through this stage. This stage will last for different lengths of time for different people. Usually, you will notice an improvement in your skin conditions around three to four months after you begin treatment. After the purge period is over then people report that their skin is the best it ever has been. This is because the old, damaged skin cells have been replaced with healthy new ones.

The Tretinoin ‘purge’ is a phase of treatment that has been coined as a skin purge by people that have used the medication. During this phase, your skin will seemingly worsen. You may become concerned at this point, however, there is no need to be, as this is completely normal and is part of the process of rejuvenating your skin. The purge occurs as the medication is rapidly exfoliating the skin which brings out hidden or dormant acne. Once this phase has cycled through your old damaged skin cells then the cream will work to create healthy new cells.

Tretinoin can seem slightly daunting when you begin to use it because of the purge phase. Here are a few tips on how to use Tretinoin and how to ensure you stick with it. Use suncream. Tretinoin use can make your skin very sensitive to sunlight. It is recommended that you use a high-SPF sun cream when you go outside to avoid any sun damage. Take photos to track progress. Throughout the process of using Tretinoin, you may wish to take photos regularly so that you can monitor your progress. This will give you something to look back on to see where you were before and where you are after using the cream. Stick with it. When people are going through the purge phase they may be tempted to quit using Tretinoin altogether. It is important that you stick with your treatment as you will only begin to experience its true benefits after this phase. Know about the possible side effects and do your research. You should always do your research before you start using Tretinoin. If you know what to expect before any cream has even touched your skin you are much more likely to stick with it and are much more likely to experience its benefits.

Tretinoin and Retinol are very similar medications. They are both derivatives of Vitamin A and they are both used to help improve the health of the skin. The main difference is the strength of both medications. Tretinoin is a stronger, prescription-only medication that is used to treat acne, wrinkles and fine lines. Retinol on the other hand is an over-the-counter skin treatment that is often found as an ingredient in skincare products. Retinol is of a lower strength than Tretinoin and is less likely to cause ‘purge’ like side effects, however, this does mean it may have fewer benefits.

Tretinoin vs Retinol

UK Meds have put together a Google Web Story summarising how the acne treatments Tretinoin and Retinol compare. Take a look at it below:

Interested in finding out more? Read our blog 'Tretinoin vs Retinol'.

Yes, the results that you can get from using Tretinoin make it worth it, especially if you have been struggling with your acne for long periods of time. It can be hard for people to look ahead when they are in the skin purge phase. It is important that you stick with your medication as the general consensus is that the results you experience will be worth it.

Tretinoin is pronounced - tre-ti-nowin - in British English.

Buy Tretinoin

Where To Buy Tretinoin UK

You can safely & conveniently buy Tretinoin in the UK from UK Meds.

Tretinoin Boots

At the time of writing, Tretinoin cream is not available at Boots. However, should you wish to purchase Tretinoin, you can do so at UK Meds. Additionally, if you would like to purchase more than one tube of Tretinoin cream, you can benefit from further savings at UK Meds.

Tretinoin Cream Amazon

At the time of writing, Tretinoin cream is not available at Amazon. However, should you wish to purchase Tretinoin, you can do so at UK Meds. Additionally, if you would like to purchase more than one tube of Tretinoin cream, you can benefit from further savings at UK Meds.

Tretinoin Superdrug

At the time of writing, Tretinoin cream is not available at Superdrug. However, should you wish to purchase Tretinoin, you can do so at UK Meds. Additionally, if you would like to purchase more than one tube of Tretinoin cream, you can benefit from further savings at UK Meds.

Tretinoin UK

You can purchase Tretinoin online from UK Meds simply select your treatment, complete a short consultation so that we can ensure it is right for you, select your delivery method and then sit back and relax whilst we do the rest! Please note that Tretinoin cream outer packaging is in French and has a valid product licence for Europe.

Google Web Stories

How To Use Tretinoin

Our Google Web Story below explains how to use tretinoin cream in a simple and visual way, perfect for when you're on the go:

A-Z Guide to Tretinoin

Can you get tretinoin on the NHS?

How To Get A Prescription For Tretinoin Cream In The UK

Tretinoin Reviews

Here are some reviews from real Tretinoin users:

"I have been using Tretinoin cream for 24 years. After "decades" of use, I consider it a miracle cream. I started at 36. I'm now 60 and have the skin texture (porcelain-like) of a 20-something."

"After about only 3 and a half weeks of using it, I couldn't be more pleased. My scars have significantly faded, I have 0 pimples. My face looks amazing. I can literally walk around without makeup."

To read more Tretinoin reviews, check out


Content author

Scott Weaver

Medical Content Writer • Bachelor of Arts Degree

Scott is an experienced, skilled content writer dedicated to creating helpful and accessible medical content for UK Meds.

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Medical Reviewer

Medical Reviewer

Alexis Missick

General Practitioner (GP) • MBChB

With a decade of experience in the NHS and six years internationally, Alexis is a seasoned General Practitioner hailing from Turks and Caicos.

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