What Is NAD+ Biohacking?

NAD+ biohacking is the practice of using lifestyle strategies, supplements, and therapies to boost levels of NAD+ (Nicotinamide Adenine Dinucleotide) in the body. NAD+ is a natural molecule found in all living cells and plays a vital role in producing energy, repairing DNA, supporting brain function, and slowing the effects of ageing. Biohacking NAD+ means making targeted changes to help your body stay energised, focused, and healthy for longer.

Why do people want to boost NAD+?

As we get older, our NAD+ levels decline. This can lead to tiredness, slower recovery, brain fog, and signs of ageing. By increasing NAD+ through biohacking, people aim to:

Feel more energised and alert
Support mental clarity and memory
Enhance physical performance and recovery [1] [2]
Protect cells from damage and inflammation
Slow down the ageing process at the cellular level

What are the most popular NAD+ biohacks?

There are several science-backed ways to support NAD+ levels, including:

1. Lifestyle Biohacks

Exercise – especially moderate-intensity cardio and strength training
Intermittent fasting – may naturally increase NAD+ and activate repair pathways
Good sleep – supports natural energy production and repair
Stress reduction – lowers inflammation that can deplete NAD+

2. Nutritional Biohacks

Eating foods rich in vitamin B3 (e.g. salmon, mushrooms, chicken, and peanuts)
Following a balanced, antioxidant-rich diet to reduce oxidative stress

3. Supplement Biohacks

NMN (Nicotinamide Mononucleotide) – a popular supplement that helps the body make NAD+
NR (Nicotinamide Riboside) – another well-researched NAD+ precursor
Resveratrol – a natural plant compound thought to support sirtuins and NAD+ activity

4. Advanced Therapies

NAD+ IV therapy – delivers NAD+ directly into the bloodstream for quicker absorption
NAD+ injections – a faster alternative to oral supplements, used under medical supervision

Is NAD+ biohacking safe?

Most NAD+ biohacking methods are considered safe when done correctly. Basic lifestyle changes like better sleep, diet, and movement are low risk. Supplements such as NMN and NR are generally well tolerated, but it’s always best to speak to a healthcare professional before starting anything new, especially if you take other medications or have a health condition.

Who might benefit from NAD+ biohacking?

NAD+ biohacking may be helpful for:

Adults aged 30 and over looking to support energy and focus
People recovering from burnout or chronic fatigue
Athletes or those with physically demanding lifestyles
Anyone interested in supporting healthy ageing and longevity

Key Takeaways

NAD+ biohacking is about increasing NAD+ levels to support energy, brain function, and healthy ageing.
Simple strategies like exercise, better sleep, and a healthy diet can support natural NAD+ production.
Popular supplements include NMN and NR, which help the body make more NAD+.
NAD+ IV or injection therapy may offer faster results under professional care.
Always check with a healthcare provider before starting supplements or advanced therapies.

Reminder: NAD+ biohacking is not about quick fixes, it’s about supporting your body from the inside out. With the right habits, you can help your cells stay strong, energised, and healthy for years to come.

Sources

[1] Rajman L, Chwalek K, Sinclair DA. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metab. 2018 Mar 6;27(3):529-547. doi: 10.1016/j.cmet.2018.02.011. PMID: 29514064; PMCID: PMC6342515.

[2] Freeberg KA, Udovich CC, Martens CR, Seals DR, Craighead DH. Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions. J Gerontol A Biol Sci Med Sci. 2023 Dec 1;78(12):2435-2448. doi: 10.1093/gerona/glad106. PMID: 37068054; PMCID: PMC10692436.