NAD+ Capsules

At a glance

• What it is: a food supplement providing 500mg of beta-nicotinamide adenine dinucleotide (NAD+) in each enteric-coated, liposomal capsule.
• Who tends to use it: adults who want to support everyday energy, focus and healthy ageing, and anyone who prefers an oral, needle-free alternative to NAD+ injections.
• How to take it: one capsule each morning, on an empty stomach.
• No prescription needed: this is a supplement, not a medicine, so you can buy it directly with next-day UK delivery.
• Good to know: if your tiredness is persistent or unexplained, see your GP, because fatigue can have underlying causes worth checking.

"NAD+ is a coenzyme found in every cell in your body, and it plays a central role in turning the food you eat into usable energy. Research shows that our natural NAD+ levels decline as we age, which is one reason interest in NAD+ supplements has grown so quickly. Vivere's capsules provide NAD+ directly, in a liposomal, enteric-coated form designed to survive digestion, so they are a convenient way for adults to support their NAD+ intake day to day. We would always say a supplement works best alongside good sleep, regular movement and a balanced diet rather than in place of them. And if you are feeling tired all the time, please do not simply reach for a supplement and leave it there. Persistent fatigue deserves a proper look from your GP, because it can point to things like low iron, an underactive thyroid or other conditions that need their own treatment."

- UK Meds Clinical Team

NAD+ Liposomal Capsules by Vivere are an oral food supplement that provides a concentrated dose of nicotinamide adenine dinucleotide, better known as NAD+. NAD+ is a coenzyme, a helper molecule that enzymes need in order to work, and it is present in every living cell. Each capsule contains 500mg of the active form, beta-nicotinamide adenine dinucleotide (beta-NAD), held in a liposomal, enteric-coated capsule so more of the NAD+ can survive stomach acid and reach the bloodstream.

The formula is designed for high bioavailability, which simply means the amount your body can actually absorb and use. Alongside the active NAD+, each capsule contains acacia gum and phospholipids, the delivery agents that help form the liposomal coating.

You can buy NAD+ Liposomal Capsules by Vivere directly from UK Meds. Because NAD+ is a food supplement rather than a prescription-only medicine, you do not need a prescription or an online consultation to order it. The process is the same as buying any other supplement online:

1. Choose your NAD+ Liposomal Capsules by Vivere and add them to your basket.
2. Check out securely and enter your delivery details.
3. Your order is dispatched from our UK pharmacy for fast, tracked delivery to your door.

UK Meds is a registered UK pharmacy, so your supplement order is handled by a regulated team. If you take regular medication, live with a long-term condition, or you are simply not sure whether NAD+ is right for you, our pharmacy team is on hand to answer questions before you buy.

Age-related NAD+ decline is the gradual fall in your cells' NAD+ levels as you get older. It is a normal part of ageing rather than a disease, but it matters because so many essential processes depend on NAD+, from producing energy in your mitochondria to supporting the enzymes that maintain and repair your DNA. When the available pool of NAD+ shrinks, cells have less of the coenzyme to share across all of these jobs.

Scientists first confirmed this decline in people in a landmark 2012 study of human skin tissue, which found NAD+ levels dropped steadily with age.1 A widely cited 2021 review in Nature Reviews Molecular Cell Biology and a 2024 review in Aging Cell have since described how NAD+ availability falls across many tissues and why that shift is linked with the biology of ageing.2,3 The exact amount of decline varies between tissues and studies, so it is more accurate to say NAD+ tends to fall substantially by mid-life than to quote a single fixed percentage.

How the body's NAD+ levels tend to decline with age.

Feeling tired is one of the most common health complaints in the UK, and it becomes more noticeable for many people as they age. UK population surveys suggest that between 10% and 18% of adults report tiredness or fatigue that lasts a month or longer, and around half of people living with a long-term condition say they often feel tired or run down.4 Tiredness is also one of the most frequent reasons people book to see their GP.

NAD+ decline itself is effectively universal, because everyone's NAD+ levels shift downward with age. That is part of why NAD+ has become such a talked-about topic in longevity and biohacking circles, and why oral NAD+ supplements, NAD+ injections and precursors like NR and NMN have grown so quickly in popularity.

NAD+ levels fall with age because your cells make less of it while using more of it up. Rather than one single cause, it is a combination of shifts in how NAD+ is produced, recycled and consumed. The main factors researchers point to include:

• Slower production and recycling: the enzymes that build and salvage NAD+ become less efficient over time.
• Higher demand from repair enzymes: accumulated DNA damage activates PARP enzymes, which consume NAD+ as they work.
• Increased breakdown: an enzyme called CD38, which rises with age and low-grade inflammation, uses up NAD+.
• Lifestyle pressures: poor sleep, low physical activity, a nutrient-poor diet, heavy alcohol use and excess sun exposure can all add to the strain on your NAD+ pool.

These mechanisms are described in the same Nature Reviews Molecular Cell Biology and Aging Cell reviews noted above.2,3 Research in Cell Metabolism has also shown that the enzyme CD38 is a major driver of the age-related fall in NAD+.5

People often associate declining NAD+ with a general dip in energy and sharpness rather than any single symptom. Commonly mentioned experiences include lower daytime energy and stamina, slower recovery after exercise, and a feeling of mental fog or reduced focus. It is worth being clear that these are everyday, non-specific feelings, and they can have many causes. They are not a way to diagnose low NAD+, and no supplement should be used to self-treat a symptom that is bothering you. If any of these are persistent, speak to a healthcare professional.

NAD+ capsules provide the coenzyme directly, whereas most alternatives provide a precursor that your body then has to convert into NAD+. The table below sets out the main options factually so you can see how they differ. None is presented as superior, because the right choice depends on your goals, budget and preferences.

The practical takeaway is that direct NAD+, whether in a capsule or an injection, skips the conversion steps that a precursor such as NMN or vitamin B3 has to go through. For background, authorised UK and EU health claims recognise that vitamin B3 (niacin) contributes to normal energy-yielding metabolism and to the reduction of tiredness and fatigue, which is one reason the wider vitamin B3 family is so closely tied to energy.

Most human research so far has tested NAD+ precursors rather than NAD+ itself. A landmark trial showed that nicotinamide riboside is orally bioavailable and raises NAD+ in people,6 and a 2021 clinical trial found that NMN improved muscle insulin sensitivity in prediabetic women.7 Direct oral NAD+, like the NAD+ in these capsules, is a newer format with less human trial evidence so far, which is worth bearing in mind.

"People often ask us whether to choose capsules or injections, and there is no one-size-fits-all answer. Injections deliver NAD+ directly and tend to suit a more intensive routine, while capsules are simple, needle-free and easy to keep up day to day. Many of our customers use both, leaning on capsules for maintenance and for travelling. The best option is the one you will actually stick to."

- UK Meds Clinical Team

The most popular ways to support NAD+ in the UK are oral capsules, NAD+ injections, IV drips and NR/NMN supplements. Oral NAD+ capsules are the most convenient and travel-friendly, which makes them a common everyday choice and a popular companion to injections. Many people use NAD+ injections by Vivere for direct delivery, then keep NAD+ capsules on hand for maintenance, for travelling, or simply for the days they would rather not inject.

If you are weighing up capsules against injections specifically, the table below sets out the main practical differences at a glance.

NAD+ capsules work by increasing the NAD+ available to your cells, so there is more of the coenzyme to go around. NAD+ acts as an electron carrier in the reactions that turn food into adenosine triphosphate (ATP), the main energy currency produced by your mitochondria. In simple terms, NAD+ is a shuttle that moves electrons through energy metabolism.

NAD+ is also the fuel used by two important enzyme families. Sirtuins draw on NAD+ to help regulate cellular health and metabolism, and PARP enzymes use it during DNA repair and cellular maintenance. Because all of these processes tap the same NAD+ pool, keeping that pool topped up is the logic behind supplementation. The liposomal, enteric coating on Vivere's capsules is designed to protect the NAD+ from stomach acid and improve how much is absorbed, which supports its systemic availability.

The wider role of NAD+ in energy, metabolism and ageing is set out in a 2015 review in Science,8 and the evidence for raising NAD+ with supplements is weighed up in a 2018 review of NAD-boosting molecules.9

How NAD+ helps your cells make energy and supports DNA repair.

"The thinking behind supplementing is simple. So many processes draw on the same pool of NAD+ that the aim is just to keep that pool well stocked. With an oral product, what really matters is how much survives digestion, which is why Vivere use a liposomal, enteric-coated capsule rather than a plain powder."

- UK Meds Clinical Team

Take one capsule each morning on an empty stomach. Taking NAD+ early in the day fits with your natural circadian rhythms, so the lift in cellular energy supports your active hours rather than your sleep. Always follow the directions on the product label, and do not exceed the recommended daily dose.

The supplement information panel, showing the 500mg NAD+ dose and ingredients.

NAD+ capsules are intended for healthy adults who want to support their everyday energy, focus and healthy ageing. They tend to suit:

• Adults, and especially those over 30, who notice their energy is not what it was.
• People interested in longevity and biohacking who want a simple daily routine.
• Anyone who prefers an oral, needle-free option instead of, or alongside, NAD+ injections.
• Frequent travellers, since the capsules do not need refrigeration.
• Athletes and drug-tested individuals, thanks to the Informed Sport certification.

They are not suitable for under-18s, and some groups should take extra care (see warnings below).

Most people tolerate NAD+ supplements very well, and any side effects are usually mild and temporary, particularly in the first week or two as your body adjusts. The most commonly reported effects are:

• Mild nausea or stomach discomfort
• Occasional headaches
• A short-lived dip in energy as your routine settles
• Slight indigestion

Human studies of NAD-boosting supplements such as NR and NMN have generally reported good tolerability. The first human study of oral NMN found no safety concerns,10 and a randomised trial of nicotinamide riboside in healthy middle-aged and older adults reported that it was well tolerated.11 These studies tested precursors rather than direct NAD+, but they are reassuring about this class of supplement.

If any effect is severe, persistent or worries you, stop taking the supplement and speak to a pharmacist or doctor.

Some people should get personalised advice before taking NAD+ capsules. Please speak to your GP, pharmacist or a qualified healthcare professional first if you:

• Are pregnant or breastfeeding, in which case it is best to avoid supplementation unless a doctor advises otherwise.
• Have a pre-existing liver condition, diabetes, or another long-term health condition.
• Are currently receiving cancer treatment or have a history of cancer.
• Take prescription medication, so any interactions can be checked.

Keep out of the reach and sight of children. Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle.

See your GP if you feel tired all the time, if your fatigue is severe, or if it does not improve with rest and better sleep. Persistent or unexplained tiredness can be a sign of an underlying condition that needs its own treatment, such as iron-deficiency anaemia, an underactive thyroid, diabetes, sleep apnoea, depression or vitamin deficiency. A supplement is not a substitute for that assessment. You should seek prompt medical advice if tiredness comes with symptoms such as unexplained weight loss, breathlessness, a persistent fever, or if you simply feel something is not right. The NHS has helpful guidance on tiredness and fatigue if you would like to read more.12 A 2024 UK primary-care cohort study found that people who saw their GP with fatigue had a higher underlying risk of several conditions, which is exactly why persistent tiredness is worth getting checked.13

Your daily habits influence how much strain your NAD+ pool is under. The factors most often linked with NAD+ include:

• Sleep: poor or broken sleep works against the recovery processes NAD+ supports.
• Physical activity: regular exercise is associated with healthier NAD+ metabolism.
• Diet: vitamin B3 (niacin) and the amino acid tryptophan, found in foods such as meat, fish, eggs, dairy, wholegrains and legumes, are the raw materials your body uses to make NAD+.
• Alcohol: heavy drinking places extra demand on NAD+.
• Sun exposure: UV damage to skin activates repair enzymes that draw on NAD+.
• Chronic inflammation and ageing: both increase NAD+ consumption over time.

Yes. The most reliable ways to support your NAD+ metabolism are everyday habits rather than any single product. Getting consistent, good-quality sleep, staying physically active, eating a balanced diet rich in vitamin B3 sources, moderating alcohol and protecting your skin from excess sun all help. Some people also explore time-restricted eating or fasting, which research has linked with NAD+ metabolism, though the evidence in humans is still developing. A supplement such as NAD+ capsules is best thought of as one part of this bigger picture, not a replacement for it.

Many users report a gradual lift in daily energy and mental clarity over the first few weeks of consistent use, along with a sense of recovering more comfortably after exercise and less of the mental fog they describe as brain fog. These are personal accounts rather than guaranteed outcomes, and individual experiences vary. What most reviewers agree on is that a daily capsule is an easy habit to keep, especially compared with injecting, which is a large part of why oral NAD+ has become so popular.

"If you decide to try NAD+ capsules, give them a fair run. Take one each morning and judge how you feel over a few weeks rather than a few days, because everyone responds differently. A supplement is not a switch you flick, so keep your expectations realistic and remember that sleep, movement and diet still do most of the work."

- UK Meds Clinical Team

Getting started is straightforward. Add NAD+ Liposomal Capsules by Vivere to your basket, check out, and we will dispatch your order from our UK pharmacy with fast, tracked delivery. Once your capsules arrive, take one each morning on an empty stomach and give the routine a few weeks to become part of your day. If you already use NAD+ injections, capsules can slot in neatly between cycles or while you are travelling.

Is NAD+ the same as NMN?

No. NMN (nicotinamide mononucleotide) is a precursor that your body converts into NAD+, whereas these capsules provide NAD+ directly. That means NAD+ capsules skip the conversion step that NMN has to go through.

Do I need a prescription to buy NAD+ capsules in the UK?

No. NAD+ Liposomal Capsules by Vivere are a food supplement, not a prescription-only medicine, so you can buy them directly from UK Meds without a prescription or an online consultation.

Can I take NAD+ capsules on an empty stomach?

Yes, and it is recommended. Take one capsule in the morning on an empty stomach.

How long does it take to notice a difference?

It varies from person to person. Many users say they notice a difference in energy and focus after around two to four weeks of daily use, although this is based on personal reports rather than a guaranteed result.

Can I take NAD+ capsules with NAD+ injections?

Both capsules and injections are ways to support your NAD+ levels, and many people use them together. Capsules are a convenient option between injection cycles or while travelling, since they do not need refrigeration. If you are combining them, it is sensible to check with a healthcare professional first.

Are NAD+ supplements safe and legal to buy in the UK?

NAD+ is sold in the UK as a food supplement and is generally well tolerated by healthy adults. As with any supplement, it is best to check with your GP or pharmacist before starting if you are pregnant or breastfeeding, take regular medication, or have a health condition.

How much NAD+ is in each capsule?

Each capsule contains 500mg of beta-nicotinamide adenine dinucleotide (NAD+). The recommended dose is one capsule per day.

NAD+ Liposomal Capsules by Vivere are best thought of as one convenient, well-made part of a healthy ageing routine rather than a quick fix. Here is our honest closing view.

"NAD+ has become one of the most talked-about topics in healthy ageing, and it is easy to get swept up in the hype. Our honest view is that NAD+ Liposomal Capsules by Vivere are a convenient, well-made way for healthy adults to support their NAD+ intake, and a sensible needle-free choice if you would rather not inject. They are not a magic bullet, and they work best as part of a routine that also includes good sleep, regular movement and a balanced diet. If you are generally well and curious, they are an easy thing to try. If you are feeling persistently tired or run down, please start with your GP rather than a supplement. And if you are ever unsure whether NAD+ is right for you, our pharmacy team is happy to help before you buy."

- UK Meds Clinical Team

The information on this page is for general informational purposes only and should not replace personalised advice from a qualified healthcare professional. NAD+ Capsules by Vivere are a food supplement and are not intended to diagnose, treat, cure or prevent any disease. Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. Always read the label, and speak to your GP or pharmacist before starting any new supplement, particularly if you are pregnant or breastfeeding, take medication or have a health condition.

Our content is regularly reviewed by our team of medical experts and registered healthcare professionals to make sure it stays accurate, up to date and aligned with current evidence on NAD+ and cellular health. If you spot anything that needs updating, please let us know.

Key studies, trials and reviews

1. Massudi H, Grant R, Guillemin GJ, Braidy N. Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLOS ONE. 2012;7(7):e42357. Read the study.
2. Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology. 2021;22(2):119-141. Read the review.
3. Chini CCS, et al. NAD metabolism: Role in senescence regulation and aging. Aging Cell. 2024. Read the review.
4. Patient (clinical reference). Fatigue and tiredness (TATT), collating UK primary-care and population survey data. Read the reference.
5. Camacho-Pereira J, et al. CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism. Cell Metabolism. 2016;23(6):1127-1139. Read the study.
6. Trammell SAJ, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications. 2016;7:12948. Read the study.
7. Yoshino M, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229. Read the trial.
8. Verdin E. NAD+ in aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208-1213. Read the review.
9. Rajman L, Chwalek K, Sinclair DA. Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metabolism. 2018;27(3):529-547. Read the review.
10. Irie J, et al. Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocrine Journal. 2020;67(2):153-160. Read the study.
11. Martens CR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications. 2018;9:1286. Read the trial.
12. NHS. Tiredness and fatigue. Read the NHS guidance.
13. Underlying disease risk among patients with fatigue: a population-based cohort study in primary care. British Journal of General Practice. 2024. Read the study.

Further reading

• NHS: B vitamins and folic acid (including niacin, vitamin B3)
• UK Meds: NAD+ injections by Vivere