Orlistat

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Orlistat

Orlistat capsules are for those who suffer from obesity. It helps block the absorption of fat within the digestive tract. The end result is that fat molecules pass through the gut, into stool, instead of being processed and added to fat layers beneath your skin.

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Orlistat

One of the leading causes of death nowadays is obesity and it is estimated that a huge portion of the population suffers from this problem. In fact, the problem has grown to an alarming proportion that a lot of agencies from government to private groups are pushing for ways to lose weight. These methods range from fad diets to exercise machines, to medications, to something as extreme as surgery. Orlistat is one of those drugs that have been introduced so as to combat obesity.

Orlistat is a drug designed to treat obesity. It is marketed as a prescription drug under the trade name Xenical by Roche in most countries, and is sold over-the-counter as Alli by GlaxoSmithKline in the United Kingdom and the United States. Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet.

Orlistat is used with a doctor-approved exercise, behavior change, and reduced-calorie diet program to help you lose weight. It is used by certain overweight people, such as those who are obese or have weight-related medical problems. Taking orlistat can also help keep you from gaining back weight you have lost. Losing weight and keeping it off can lessen the many health risks that come with obesity, including heart disease, diabetes, high blood pressure, and a shorter life.

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Dosage

  • The recommended prescription dose for Xenical is one capsule (120 mg) three times daily.
  • The recommended dose for alli is 60 mg three times daily.
  • Orlistat should be taken one hour after or during a meal containing about 15 mg of fat. Meals without fat do not require this pill.
  • No additional benefit has been shown when taken in doses greater than 120 mg.
  • Patients should eat a nutritionally balanced, reduced calorie diet that contains approximately 30% of calories from fat.
  • Alli includes an individually tailored online weight loss support program.

Orlistat is a white to off-white crystalline powder. It is practically insoluble in water, freely soluble in chloroform, and very soluble in methanol and ethanol. It has no pK within the physiological pH range.

XENICAL is available for oral administration as a turquoise hard-gelatin capsule. The capsule is imprinted with black. Each capsule contains a pellet formulation consisting of 120 mg of the active ingredient, orlistat, as well as the inactive ingredients microcrystalline cellulose, sodium starch glycolate, sodium lauryl sulfate, povidone, and talc. The capsule shell contains gelatin, titanium dioxide, and FD&C Blue No. 2 with black printing ink containing pharmaceutical grade shellac, propylene glycol, strong ammonium solution, potassium hydroxide and black iron oxide.

From 1 in 250 and 1 in 70 patients experienced one or more of these symptoms in the first year. Generally, the side effects occurred within three months of starting therapy. In about 50% of patients, the side effects resolved within one to four weeks, but the effects in some patients lasted six months or longer. To reduce the occurrence of these side effects, meals should contain no more than 30% fat because it is the unabsorbed fat that causes most of the symptoms. alli causes fewer side effects because it contains half the dose of prescription-strength. Patients with a history of oxalate kidney stones may develop increased levels of oxalate in their urine, which may increase the risk of kidney stones.

Orlistat (prescription and nonprescription) is used with an individualized low-calorie, low-fat diet and exercise program to help people lose weight. Prescription strength is used in overweight people who may also have high blood pressure, diabetes, high cholesterol, or heart disease. It is also used after weight-loss to help people keep from gaining back that weight. Orlistat is in a class of medications called lipase inhibitors. It works by preventing some of the fat in foods eaten from being absorbed in the intestines. This unabsorbed fat is then removed from the body in the stool.

It acts in your gut, stopping enzymes that break down fats from doing their job properly, says Deena Adimoolam, M.D., Assistant Professor of Diabetes, Endocrinology and Bone Disease, Icahn School of Medicine at Mount Sinai. Specifically, it inhibits pancreatic lipase, meaning fats can pass undigested through the body, reducing the number of calories you absorb. When you take an orlistat-based med with a meal, about 30 percent of the fat you consume won’t be broken down in your gut.

Orlistat is a drug designed to treat obesity. Its primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake. It works by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested.

Orlistat is only part of a complete program of treatment that also includes diet, exercise, and weight control. Your daily intake of fat, protein, and carbohydrates should be evenly divided over all of your daily meals. Follow your diet, medication, and exercise routines very closely.

Avoid a diet that is high in fat. High-fat meals taken in combination with orlistat can increase your risk of unpleasant side effects on your stomach or intestines.

What is Orlistat and how does it work?

Orlistat is a prescription drug but it does have a form that is sold over-the-counter. It is primarily designed to treat obesity by preventing the body from absorbing the fats that you eat. The drug acts on the lipase inhibitor in the body which reduces the overall calorie intake of the person. Because of this calorie intake reduction, obese people can expect to lose weight even while eating the same items as long as they still spend more calories than what they ingest aside from the fats. This is why this medicine is used along with supervised reduced-caloric diet so as to be effective. This medication has a definite effect although it is small if on its own which is why it needs to be part of a proper weight loss program for it to be effective.

Contraindications for use

Despite how effective it is, just like any kind of drug, it will have certain drug-to-drug interactions that you need to be wary of. It can also affect your body differently so you need to take the medication carefully. For instance, pregnant women should take this medication as weight loss is ill-advised when pregnant. The loss of dietary fats may also cause problems for the developing child. Another sure contraindication when taking the medicine is allergic reactions. If you develop an allergic reaction to taking the medicine, then immediately stop taking it and seek medical consult immediately. People become allergic to various medications differently and the cause for such isn’t clear. However, if you experience an allergic reaction to the drug, then stop immediately since it can actually lead to death.

Side effects and precautions

As with other medications, since it has a positive effect in the body, as a consequence, it will have a negative effect in the body as well in response to the chemical changes in the body. Some of these may not be harmful to the body; just something different that you need to anticipate that might happen. One of the biggest side effects that Orlistat users get is a change in their bowel function. Since the drug inhibits the absorption of fats in the diet, then this means that the fat you eat will have to go out in pretty much the same form and way. This will mean that your stool will become fatty and oily. You may also experience an oily discharge that may happen without warning. This also increases your bowel movements per day as well as making it more difficult to control.