Please note: Due to high order volumes, deliveries may take a little longer than usual. Thank you for your patience.

Mounjaro (Tirzepatide) Injections

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Mounjaro is a once-weekly injectable pen that contains tirzepatide, a medicine shown to support weight loss by helping regulate blood sugar and reduce appetite. Clinical trials have reported up to 20% body weight reduction over 18 months. It may also be prescribed to adults with type 2 diabetes as part of an overall plan to improve metabolic health.

Mounjaro is a cold-chain medication and must be stored in the fridge (2°C to 8°C). It can be kept out of the fridge for up to 21 days, provided the temperature stays below 30°C.

We also offer alternative weight loss treatments such as Wegovy (semaglutide) and Saxenda (liraglutide), as well as the diabetes treatment Ozempic (semaglutide).

Please Note: Due to high demand, some patients may experience a delay when ordering Mounjaro. If your order is showing as 'on-hold' this means we are currently waiting for stock to arrive. Thank you for your patience.

  • Effectiveness: Avg. ~22% weight loss*
  • Dose: One weekly single dose (One pen per month)
  • Contains Tirzepatide
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Mounjaro (Tirzepatide) Injections reviews

More information

A Doctor's Take On Mounjaro As Treatment For Weight Loss

Dr Shane Charles (MBBS, MRCS, PgDip SEM) - GMC Number 8085739

GP and surgeon, Dr Shane Charles (MBBS, MRCS, PgDip SEM) provides a simple explanation of the medication below:

'Mounjaro (Tirzepatide) is a medication used for the treatment of Type 2 diabetes mellitus (T2DM), and can also be used as a weight loss treatment. It works by increasing the effects of the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors'.

If you think this is a treatment that can help you, start an online consultation now for a registered prescriber to review. If treatment is deemed suitable, they can prescribe it, and we can deliver it to you from the comfort of your own home with a range of convenient delivery and payment options for you to choose from. If you have any questions about a medication, you should always consult your doctor with any questions prior to starting treatment, to ensure that it is safe and suitable for you.

Patient Information Leaflet

For more information on this prescription medication patients should refer to the Mounjaro patient information leaflet.

Get to know the Mounjaro KwikPen

Overview

Condition it treats:Weight loss; Type-2 Diabetes
Type of drug:Dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist
Brand names:Mounjaro
Active ingredient:Tirzepatide
Available strengths:2.5mg, 5mg, 7.5mg, 10mg, 12.5mg, 15mg
Common side effects:Diarrhoea, decreased appetite, nausea, vomiting, indigestion, constipation, stomach pain

What is Mounjaro?

Mounjaro (tirzepatide), pronounced “mown-JAHR-oh”, is a once-weekly injectable medicine used to treat type 2 diabetes and support weight loss. It works by regulating blood sugar, reducing appetite, and curbing cravings, especially when combined with a calorie-controlled diet and regular exercise.

What is the eligibility criteria?

Mounjaro is typically prescribed to adults who meet one of the following criteria:

  • Have a BMI of 30 or higher (classified as obese)
  • Have a BMI of 27 or higher and a related health condition such as:
    • Prediabetes
    • High blood pressure
    • High cholesterol
    • Heart disease

Consult a healthcare professional to determine if Mounjaro is suitable for you.

For more information, visit our Beginner's Guide to Mounjaro.

How does Mounjaro work?

Mounjaro contains tirzepatide, a dual-action GLP-1 and GIP receptor agonist. These two naturally occurring gut hormones help regulate blood sugar and appetite:

  • GLP-1 (Glucagon-Like Peptide-1): Reduces hunger and supports blood sugar control.
  • GIP (Glucose-Dependent Insulinotropic Polypeptide): Enhances insulin response and appetite regulation.

How does Mounjaro supports weight loss

  • Regulates blood sugar to reduce cravings and maintain stable energy
  • Suppresses appetite by mimicking fullness hormones
  • Slows digestion to keep you feeling full longer
  • Improves energy balance by working with the brain and fat cells

Its dual-action mechanism makes Mounjaro more effective for weight loss than GLP-1–only treatments like Wegovy and Ozempic (Nauck & D'Alessio, 2022).

How long does Mounjaro take to work?

Mounjaro starts working right away, but noticeable improvements in appetite and blood sugar may take a few weeks. For best results, follow your doctor’s guidance and maintain a healthy lifestyle.

Possible Mounjaro Weight Loss Results

Clinical studies show that Mounjaro (Tirzepatide) can support significant and sustainable weight loss when combined with healthy lifestyle changes. Research suggests that people using Mounjaro may achieve up to 22.5% body weight loss over a 72-week period (around one year and four months). Many people begin to notice results within the first 4 to 6 weeks.

Real-World Weight Loss Examples from Trials

One of the largest Mounjaro studies involved 2,539 adults who received either a placebo or a weekly dose of 5mg, 10mg or 15mg of Mounjaro for 72 weeks. All participants started on 2.5mg once a week for the first four weeks, during which they lost an average of 3% of their starting body weight.

Between weeks 5 and 8, the dose was increased to 5mg weekly. By this stage, most participants had lost around 5–6% of their body weight.

From weeks 9 to 12, some people continued on 5mg, while others moved up to 7.5mg weekly. By week 12, average weight loss reached around 8% of starting body weight, regardless of the exact dose.

Long-Term Weight Loss Potential

Results from multiple trials, including the SURMOUNT-1 trial (Jastreboff et al., 2022), found that Mounjaro helped people without diabetes lose up to 22.5% of their body weight over 72 weeks. Other studies have shown:

  • 15.7% weight loss in people with type 2 diabetes (Eli Lilly, 2023)
  • 20% average weight loss over 18 months in broader populations (Singh, 2024)

Further evidence shows that Mounjaro can be up to six times more effective than diet and exercise alone, with higher doses leading to:

  • 20.9% body weight reduction within 36 weeks
  • 25.3% body weight reduction within 88 weeks (Aronne et al., 2023)
What to Expect on Your Mounjaro Journey

Mounjaro is designed for long-term weight management, not rapid weight loss. Most people see gradual, steady results that continue to build over time. How much weight you lose will depend on factors like dose progression, diet, activity level and overall health.

It’s important to remember that everyone’s weight loss journey is unique. Clinical trial results show what’s possible, but your own experience may vary. If you’re not seeing the results you expected, speak to your prescriber for personalised advice or visit our guide: Why Am I Not Losing Weight on Mounjaro?

What are people in the UK saying about Mounjaro?

People in the UK who have used Mounjaro (tirzepatide) have shared a wide range of experiences. Like any weight loss treatment, results can vary from person to person. How well it works often depends on your lifestyle, health background and how your body responds to the medicine.

Real Mounjaro Reviews

If you’d like to hear directly from others, take a look at our full list of UK customer reviews and testimonials. These real stories show how Mounjaro has supported people on their weight loss journeys and what kind of results they’ve seen.

For a wider view, you can also read international reviews on trusted medical websites such as Drugs.com and WebMD.

Why results can differ for everyone

Everyone’s experience with Mounjaro is personal. Some people may notice steady progress, while others may need time to see changes. If you’re thinking about trying Mounjaro, it’s best to speak with your GP or another qualified healthcare professional first. They can assess whether it’s suitable for you and monitor your progress if prescribed.

For more motivation and real examples, explore our collection of UK Mounjaro success stories to see how people have achieved their weight loss goals safely and effectively.

Important Mounjaro pricing update

We know price changes are worrying. Below is a clear summary of what has changed, why it happened, and the options available to you.

Why has the price increased?

Eli Lilly, the manufacturer of Mounjaro, has increased the price it charges UK providers. Our remaining stock at the previous price was allocated to earlier orders. Any new stock we buy now costs more, so new requests show the updated price. We have kept pricing as low as we can while reflecting the manufacturer increase.

Why did prices change before 1st September?

In August 2025, Eli Lilly limited how much stock we could buy at the old price. We ordered as much as possible and negotiated extra, but high demand meant our allocation was used. All new deliveries to us are charged at the higher cost, which is why new requests reflect the new price.

What if I ordered before the increase?

  • We have reserved stock for you and will honour the price shown at checkout, subject to clinical approval.
  • If you see a refund pending, your order will still be processed at the price you agreed when you placed it.

Are all treatment prices changing?

No. Only Mounjaro is affected. Prices for other treatments remain the same.

Will prices come back down?

We cannot predict future pricing. For now, we expect the new prices to remain in place.

Your options if Mounjaro has become unaffordable

  • Stay on your current lower dose if it is working for you.
  • Consider a lower dose which usually costs less and may still be effective. Read about Mounjaro dosing.
  • Explore an alternative treatment such as Wegovy, if suitable for you. Our prescribers will advise the safest starting dose and timing.
  • Use flexible payment methods. We accept PayPal, Google Pay, Visa Electron, Debit/Credit Card, and Mastercard Debit/Credit Card.

Can you offer discounts?

We run promotions where possible, but because the increase comes from the manufacturer, sale prices must reflect higher costs.

Mounjaro to Wegovy Switching FAQs

Can I switch from Mounjaro to Wegovy directly?

Yes. You should leave a 7 day gap between your last Mounjaro dose and your first Wegovy dose. Your starting Wegovy dose will depend on your current treatment and will be set by a prescriber.

Dose comparison chart

You don’t need to start over if you're thinking of making the switch from Mounjaro to Wegovy. Our clinicians can help find you a suitable Wegovy dose based on your current Mounjaro dose and tolerance. Find your current Mounjaro dose below to see the equivalent Wegovy dose.

Current Mounjaro weekly dose (mg)

Starting Wegovy weekly dose (mg)

2.5

0.25

5

0.5

7.5

1.0

10-15

1.7

One of our prescribers will always confirm your dose is safe and appropriate before any order is dispensed.

If you are thinking about switching from Mounjaro to Wegovy, see our simple guide: How to switch from Mounjaro to Wegovy.

Will I get similar results if I switch?

Mounjaro and Wegovy work differently and their dose numbers are not directly comparable. What matters is using the right medicine, at the right dose, consistently, with clinical oversight. Many people find Wegovy effective for weight management when used as prescribed alongside lifestyle changes.

Why is a washout period needed?

The 7 day gap helps prevent overlapping effects and lowers the risk of side effects.

Can I switch mid-cycle?

Yes, if clinically appropriate. Do not use both medicines together. Leave a full 7 days between injections.

FitXpress - What is it and how does it work?

Our Commitment to Keeping You Safe on Your Weight Loss Journey

FitXpress is an AI-powered, live-photo BMI verification system that ensures accurate, tamper-proof body measurements to support safe and compliant online prescribing of weight-loss medications.

Learn more about the FitXpress process.

How do I use FitXpress?

To order your chosen weight loss treatment from UK Meds you need to complete a FitXpress body scan. Here is how this process works:

1 - Select your preferred weight loss treatment from the UK Meds website.

2 - Complete our online consultation form and submit your order.

3 - You will receive an email from us prompting you to complete your FitXpress scan. Click the link in the email.

4 - Select your desired photo mode. This is either taking photos yourself, or getting someone to help you. If you select "Take Photos Myself", using the voice assistant can make your experience much easier.

5 - Take a full-body front-facing photo, and a full-body side-profile photo.

6 - Submit your photos.

7 - Your photos will be reviewed by FitXpress.

7a - If your photos fail, you will receive an email explaining why, with a prompt to retake your photos.

7b - If your body scan has passed the FitXpress assessment your consultation will be reviewed by a GMC-registered doctor. If approved, your order will be processed and dispatched to your delivery address. 

Top Tips For Using FitXpress

  • During your consultation, make sure you update your weight.
  • Avoid baggy or loose clothing.
  • Stand in a well-lit area, avoiding strong backlighting. Natural light works best.
  • Stand against a plain background (white or light-coloured walls are ideal). 
  • Make sure your photos include your whole body and match the silhouette.
  • Stand straight with your arms in an 'A' pose for the front photo and relaxed by your side for the side photo.
  • Make sure the camera angle is correct.
  • If you are struggling to take the photos yourself, try using the voice assistant to help. It makes the process much easier.

Start Your Weight Loss Journey Today: Buy Mounjaro (Tirzepatide) Online in the UK

IN STOCK NOW: Available in 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg, and 15mg doses

How to Order Mounjaro Online in the UK

To buy Mounjaro online in the UK, simply complete a quick online consultation. A registered prescriber will assess your BMI, health history, and current medications to check if tirzepatide treatment is suitable for you.

How it Works

  1. Step 1: Fill out a health questionnaire online
  2. Step 2: Complete your FitXpress bodyscan
  3. Step 3: If approved by a registered prescriber, a free private prescription will be issued to allow you to place your order securely
What to know about your UK Meds purchase:
  • Please note, all Mounjaro orders are delivered to you with a set of four needles. These are included in a zip-lock bag. This zip-lock bag is then placed inside a therapy bag, which is subsequently packed into the box. This box is then placed inside a delivery bag with your shipping label attached.
  • Due to refrigeration requirements, Mounjaro orders are shipped in temperature-controlled packaging with ice packs.
  • We are only able to provide next-day delivery for this treatment.
  • Orders placed on Fridays will include a Saturday delivery option at checkout. If the Saturday delivery option is not selected, your order will be processed on Monday or Tuesday.
  • If you place an order after 2:30pm on a Thursday on a next day service your order will be dispatched on the following Monday.
  • Please ensure someone is available to receive the delivery, as we cannot replace orders missed on the first delivery attempt.
  • UK Meds are not liable for any deliveries missed or address errors.
  • Please note: All orders for UK Meds weight loss treatments are subject to a FitXpress bodyscan to BMI bodyscan

For more information before starting the GLP-1/GIP dual-agonist treatment, read our full UK guide to buying Mounjaro.

Do You Need a Prescription for Mounjaro?

Yes, Mounjaro is a prescription-only medicine in the UK. Whether you're using it for weight loss or type 2 diabetes, a consultation is required. Learn more: Do You Need a Prescription for Mounjaro?

Can I Get a Private Mounjaro Prescription?

If you don’t qualify for treatment on the NHS, you can still access private prescriptions for this treatment through UK Meds. After clinical review, you’ll receive a free prescription and can order the medication online for home delivery.

Is it legal to buy Mounjaro online in the UK?

Yes. It is legal to buy Mounjaro (tirzepatide) online in the UK with a private prescription. While NHS access is currently limited to certain high-risk patients through specialist weight management clinics, private prescription services can provide access to suitable adults following a clinical consultation.

At UK Meds, every request for Mounjaro is reviewed by a registered independent prescriber. This ensures the treatment is appropriate and safe before it is supplied. If approved, your prescription can be processed quickly and delivered to your door in secure, temperature-controlled packaging.

Why choose UK Meds?

  • Free online consultation: No need to visit your GP – complete your health assessment online.
  • Fast, discreet delivery: Next-day delivery available with refrigerated packaging to protect your medication.
  • UK-registered pharmacies: All treatments come from trusted UK suppliers and are 100% genuine.
  • Safe and confidential service: Your information and treatment are handled with care by healthcare professionals.

If you’re thinking about starting a weight loss treatment with Mounjaro or you’ve been prescribed tirzepatide to help manage type 2 diabetes, UK Meds offers a legal, secure and convenient way to access your treatment with professional clinical support.

Delivery Options

Choose the Best Delivery Options

Decide on the best discreet delivery option for your order below.

Delivery MethodPriceDescription
Next-Day Delivery

£4.95

Delivered the next day. Monday to Saturday, if ordered before 2:30pm via Yodel. Royal Mail Tracked 24 also available.
DPD Next-Day Before 12pm£9.95Delivery before 12pm (only on weekdays) if ordered before 2.30pm.
DPD Next-Day Delivery£6.95Delivery in the UK before close of business the following working day, if ordered before 2.30pm.

Please note: Delivery options and pricing are subject to change. For the latest information on UK Meds delivery options please visit our delivery page to learn more. You can also read our other policies including our returns process.

Delivery times start once your order has been approved by a registered independent prescriber. We strongly recommend completing your FitXpress scan immediately after placing your order. Your order cannot be reviewed or approved until the scan has been successfully completed, which may delay your delivery.

Mounjaro UK Pricing

Looking to buy Mounjaro in the UK? Below is a guide to current prices for the Mounjaro KwikPen across all available strengths. Each pen contains four weekly doses and is priced based on the dosage prescribed as part of your treatment plan.

How Much Does Mounjaro Cost?

The cost per pen starts from £147.99* / month. If titrating all the way up to the maximum dose and maintaining, the annual cost is £3,257.88.

Mounjaro Doses and Prices
DosagePrice (per pen)Typical Use in Treatment PlanPrice per Dose
1 Pen - 4 x 2.5mg doses£147.99Usually started for the first 4 weeks under prescriber supervision£36.99
1 Pen - 4 x 5mg doses£194.99Typically used in the second month if well tolerated£48.74
1 Pen - 4 x 7.5mg doses£244.99May be used as part of the gradual dose increase£61.24
1 Pen - 4 x 10mg doses£274.99Used if prescribed based on response and tolerability£68.74
1 Pen - 4 x 12.5mg doses£294.99Sometimes prescribed before reaching the maximum dose£73.74
1 Pen - 4 x 15mg doses£299.99Often used as a maintenance dose if clinically appropriate£74.99

One pen contains four doses, so a pen lasts for 4 weeks.

Please note: Pricing is subject to change. For the latest information please refer to the consultation section at the top of the product information page.

Directions for use

This section explains exactly how to use the Mounjaro KwikPen safely and effectively, including where to inject, how to store it and what to do if you miss a dose.

How to use the Mounjaro pen

Mounjaro (tirzepatide) is a once-weekly injection that supports weight loss and the management of type 2 diabetes. It comes in a prefilled KwikPen, designed to make injections simple and safe to use at home. Follow the steps below to use it correctly.

Where to inject Mounjaro

  • Stomach (abdomen): Inject at least 5 cm away from your belly button.
  • Front of thighs: Ideal if you’re injecting yourself.
  • Upper arms: Usually easier if someone else helps you inject.

Rotate your injection site each week to reduce skin irritation and help your body absorb the medicine evenly. Avoid any areas that are sore, bruised, scarred or irritated.

Step-by-step guide to using the Mounjaro pen

  1. Set your dose: Turn the dial until it shows your prescribed dose.
  2. Inject under the skin: Use your stomach, thigh or upper arm as the injection site.
  3. Change the site each week: This helps prevent irritation and discomfort.

If you’d like to see the process in action, you can watch this short demonstration video:

For a detailed walkthrough, visit UK Meds’ full Mounjaro instructions.

When to take Mounjaro

Mounjaro should be taken once a week as a subcutaneous injection. Staying consistent with your injection day helps you get the best results.

  • Inject once weekly, at any time of day, with or without food.
  • Try to inject on the same day each week to keep a steady routine.
  • If you change your injection day, leave at least three full days (72 hours) between doses.

Important: Always follow your prescriber’s advice exactly. This ensures Mounjaro is safe, effective and tailored to your treatment plan.

How to store and dispose of Mounjaro pens

Proper storage and disposal help keep your Mounjaro pens safe and effective. You can find more detail in our Mounjaro storage and temperature guide.

Storage instructions

  • Keep in the fridge: Store between 2°C and 8°C in the original box to protect from light.
  • Room temperature: You can keep a pen below 30°C for up to 21 days. Discard if left out longer.
  • Do not freeze: Never use a pen that has been frozen, even if thawed.

Expiry and safety checks

  • Check the expiry date before every injection.
  • Do not use a pen past its expiry date.
  • Inspect the liquid before use – it should be clear and colourless.

Safe disposal

  • Place used pens in a sharps container from your pharmacy or healthcare provider.
  • Do not throw used pens into household or recycling bins.
  • Follow your local disposal rules for medical waste.

Mounjaro dosage schedule

Mounjaro doses are increased gradually to help your body adjust and reduce side effects. Your prescriber will confirm the best schedule for you.

Typical Mounjaro titration plan
WeeksDosePurpose
1–42.5 mg weeklyStarter dose to help your body adjust
5–85 mg weeklyIncreased if tolerated well
9–127.5 mg weeklyAdjusted depending on response
13–1610 mg weeklyReviewed for effectiveness
17–2012.5 mg weeklyMay increase if suitable
21+15 mg weeklyMaintenance dose if well tolerated

For more detail, see the Mounjaro dosing and titration guide.

What to do if you miss a dose

  • Take the missed dose within four days (96 hours) of your usual injection time.
  • If more than four days have passed, skip the missed dose and take the next one as normal.
  • Do not take two doses within three days of each other.

If you miss a few weeks, don’t worry. Mounjaro stays in your system for a while, so you can usually restart safely.

  • Simply continue with your usual dose on your regular injection day.
  • If you were about to increase your dose, you may wish to stay on your current level for an extra month before moving up.
  • To ease side effects after a break, eat smaller meals, eat slowly and stay hydrated.

Contact your prescriber if you experience severe or ongoing side effects such as nausea, vomiting or abdominal pain.

How long a Mounjaro pen lasts

  • Each KwikPen contains four doses, which lasts four weeks when used correctly.
  • If kept at room temperature (below 30°C), use within 21 days.

After the fourth dose, any liquid left in the pen is not usable. This is a buffer, not an extra dose. Using it could affect your treatment or cause side effects. Learn more in why you should not use a fifth dose of Mounjaro.

What to do if you struggle with side effects or tolerance

If you have side effects such as nausea, vomiting or diarrhoea after increasing your dose, speak to your prescriber. They may recommend staying on your current dose for longer or lowering it until your body adjusts.

Never increase your dose without medical advice. If you have ongoing concerns, read the official Patient Information Leaflet or contact your healthcare provider.

Warnings and precautions

Before starting Mounjaro (tirzepatide), it’s important to understand who can safely use it and what precautions to take. This section explains key safety information, who should avoid Mounjaro, and what to watch out for during treatment.

Important safety information

Mounjaro is generally safe when prescribed by a healthcare professional, but it is not suitable for everyone. Certain medical conditions may increase the risk of side effects or complications.

Is Mounjaro safe for everyone?

No. Some people should not use Mounjaro or should do so only under close medical supervision. Speak to your doctor before starting treatment if any of the following apply to you:

  • Thyroid cancer risk: Do not use Mounjaro if you or a close relative has ever had medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN 2).
  • Digestive conditions: Avoid Mounjaro if you have gastroparesis or other serious stomach problems, as it can slow digestion.
  • Pancreatitis: If you’ve had pancreatitis before, speak to your doctor before starting Mounjaro.
  • Low blood sugar (hypoglycaemia): If you take insulin or sulfonylureas, Mounjaro can increase the risk of low blood sugar. Regular glucose monitoring is advised.
  • Eye health: If you have diabetic retinopathy, tell your doctor, as Mounjaro may temporarily affect vision.

Who is Mounjaro suitable for?

Mounjaro is approved for adults (18 and over) who meet one of the following criteria:

  • Have a BMI of 30 or above (obesity)
  • Have a BMI of 27 or above (overweight) with a related condition such as prediabetes, high blood pressure, high cholesterol or heart disease

For best results, it should be used alongside a balanced diet and regular exercise.

Who should not take Mounjaro?

Do not use Mounjaro if you:

  • Are under 18 years old
  • Are pregnant, trying to conceive or breastfeeding
  • Have severe kidney or liver disease
  • Have type 1 diabetes
  • Are using another GLP-1 receptor agonist (such as Ozempic, Saxenda or Wegovy)
  • Have a personal or family history of medullary thyroid cancer (MTC)
  • Have severe digestive problems like gastroparesis
  • Have had pancreatitis
  • Are allergic to tirzepatide or any ingredients in Mounjaro

Pregnancy and breastfeeding

  • Pregnancy: Mounjaro should not be used during pregnancy. Stop treatment at least one month before trying to conceive.
  • Breastfeeding: It is not known whether Mounjaro passes into breast milk. Speak to your doctor before use.

Medication interactions

Mounjaro may interact with prescription or over-the-counter medicines, supplements or herbal remedies. Always tell your prescriber about all the medicines you are taking.

For a detailed list, visit Drugs.com.

Monitoring and reporting

Mounjaro is under enhanced safety monitoring in the UK. Report any side effects or unusual symptoms to your doctor, pharmacist or through the MHRA Yellow Card Scheme.

Always read the full Patient Information Leaflet before starting treatment.

Can you drink alcohol while using Mounjaro?

There are no known direct interactions between Mounjaro and alcohol, but it’s best to drink only in moderation. Alcohol can affect blood sugar levels and may worsen side effects such as nausea or dizziness. Read more in our guide Can you drink alcohol on Mounjaro?

Side effects

Like all medicines, Mounjaro (tirzepatide) can cause side effects. Most are mild and improve as your body adjusts, but some can be more serious. Knowing what to expect helps you use the medicine safely and confidently.

A pharmacist's overview of the side effects of this medication and how to manage them:

Monalisa Kapinga - Pharmacist and Clinical Safety Officer - GPhC Number 2232744

Independent pharmacist and Clinical Safety Officer, Monalisa Kapinga provides a simple explanation of the common side effects of the medication and how you can manage them:

"Mounjaro may cause digestive, metabolic, and general side effects, especially when starting treatment.

Nausea, vomiting, diarrhoea or constipation are common and usually ease with time - eat small, low-fat meals, avoid rich or spicy foods, stay well-hydrated, and adjust fibre intake as needed.

Burping and general stomach discomfort can improve by eating slowly, avoiding large or fizzy meals.

Fatigue, dizziness, and general malaise often settle as your body adjusts - rest, hydrate, and ensure balanced meals.

Head rush or fainting may be linked to low blood pressure - monitor regularly and speak to your doctor if this continues.

Loss of appetite and weight loss in people with diabetes should be monitored - ensure you’re still meeting nutritional needs, and consider a dietitian review if weight loss is excessive.

Hair thinning (alopecia) may occur with rapid weight loss - usually temporary, but seek help if persistent.

Taste changes can be eased with mints or lozenges. For hypoglycaemia, especially if using insulin or sulfonylureas, monitor your glucose, carry glucose tablets, and adjust meds if needed.

Gallbladder issues (pain after fatty meals, fever) or pancreatitis (severe abdominal pain with vomiting) need urgent review - stop Mounjaro and seek medical help.

If you develop a rash, swelling of the face, lips or tongue, or breathing difficulties, stop Mounjaro immediately and go to A&E or call 999, as this could be a serious allergic reaction (angioedema or hypersensitivity)."

Common side effects

These side effects are usually mild and short term. They often improve within a few weeks as your body gets used to Mounjaro:

Common side effects of Mounjaro (tirzepatide)
Side effectWhat you might noticeTips for relief
Nausea or vomitingFeeling or being sick, especially after mealsEat smaller, lighter meals and avoid rich or greasy foods
Diarrhoea or constipationChanges in bowel habitsDrink plenty of water and include fibre in your diet
Tiredness or dizzinessFeeling low on energy or light-headedRest when needed and stay hydrated
Bloating or indigestionStomach fullness or mild discomfortEat slowly and avoid fizzy drinks
Gas or burpingIncreased flatulence or burping after mealsEat slowly and limit carbonated drinks
GallstonesPain in the upper right abdomen, sometimes after fatty mealsEat a balanced diet and report persistent pain to your GP

Tip: Eating smaller meals and drinking plenty of water can help reduce stomach upset.

Serious side effects (less common)

These side effects are rare but can be serious. If any occur, seek medical attention straight away.

Serious side effects of Mounjaro (tirzepatide)
Side effectSymptomsWhat to do
PancreatitisSevere stomach pain that spreads to your back with ongoing vomitingSeek urgent medical help
Allergic reaction (anaphylaxis)Swelling of the face, lips or tongue, or difficulty breathingCall 999 or go to A&E immediately
Gallbladder problemsPain after eating, jaundice or feverContact your GP for assessment
Low blood sugar (hypoglycaemia)Shaking, sweating, fast heartbeat or confusionEat something sugary and seek medical advice
Vision changesNew or worsening eyesight problemsReport to your doctor
Kidney problemsReduced urination, dark urine or swellingStay hydrated and contact your doctor

What to do if you have side effects

Most side effects are mild and temporary, but it’s important to know when to manage symptoms at home and when to seek medical help.

What to do if you have side effects
Type of symptomRecommended action
Mild symptomsUsually improve with rest, fluids and smaller meals. Continue your treatment and monitor how you feel.
Severe symptomsStop using Mounjaro and seek immediate medical help. Contact your GP or call 999 if symptoms are serious or persistent.

Reporting side effects

Always tell your doctor, pharmacist or nurse if you notice side effects. You can also report them through the MHRA Yellow Card Scheme.

For a full list of possible side effects, read the Patient Information Leaflet that comes with your medicine.

Alternative weight loss treatments

If Mounjaro (tirzepatide) isn’t suitable for you, there are other licensed prescription options that may help with weight loss. Your prescriber can advise on the safest and most effective choice for your health and goals.

  • Wegovy (semaglutide)
  • Saxenda (liraglutide)
  • Orlistat (also known as Xenical or Alli)

Each medicine works differently and may suit different people. Always follow the advice of a registered independent prescriber before starting treatment.

Weight loss injection comparison

The table below compares the main features of prescription weight loss treatments available in the UK.

Comparison of weight loss medicines
FeatureWegovySaxendaOrlistatMounjaro
Active ingredientSemaglutideLiraglutideOrlistatTirzepatide
How it worksGLP-1 appetite suppressantGLP-1 appetite suppressantReduces fat absorptionDual action: GLP-1 and GIP hormones
DosingWeekly injectionDaily injectionOral capsule (up to 3 times daily)Weekly injection
EffectivenessUp to 86.5% lost ≥5% body weight67.5% achieved ≥5% weight lossAround 60% lost ≥5% weightUp to 76% lost ≥5% weight
PrescriptionPrescription onlyPrescription onlyPrescription (Xenical) or pharmacy OTC (Alli)Prescription only

Mounjaro compared to other weight loss injections

Mounjaro vs Wegovy

  • Ingredients: Tirzepatide (Mounjaro) vs Semaglutide (Wegovy)
  • Mechanism: Mounjaro targets both GLP-1 and GIP, which may provide added benefit
  • Effectiveness: Both are highly effective; Wegovy has longer-term safety data

See our full guide on Mounjaro vs Wegovy.

Mounjaro vs Saxenda

  • Ingredients: Tirzepatide (Mounjaro) vs Liraglutide (Saxenda)
  • Dosing: Mounjaro is injected once weekly, while Saxenda is taken daily
  • Mechanism: Mounjaro’s dual hormone action may offer stronger appetite control

Mounjaro vs Ozempic

  • Purpose: Mounjaro is licensed for weight loss in the UK; Ozempic is prescribed for type 2 diabetes
  • Mechanism: Ozempic acts on GLP-1 only, while Mounjaro targets both GLP-1 and GIP

Learn more in our Mounjaro vs Ozempic comparison.

Switching between weight loss medications

  • Switching from Wegovy: A 4-week gap (washout period) is usually advised
  • Switching from Ozempic: Your prescriber can recommend a safe transition plan

Not sure which treatment is right for you? During your online consultation, a registered independent prescriber will review your health and recommend the most suitable option. For more comparisons, visit the UK Meds weight loss blog.

Our Commitment To Content Accuracy

UK Meds is committed to providing you with the most accurate information possible regarding healthcare and lifestyle, as outlined in our Editorial Policy and Content Policy. We aim to regularly peer review and update our content as necessary to give you the most up-to-date medical information, helping you to be fully informed before starting a consultation with a registered prescriber for the treatment that you need.

Please note that our content is not a substitute for professional medical advice. Before starting any treatment or making any changes that could affect your lifestyle, you should always speak with your doctor, pharmacist or healthcare provider to ensure that it is safe and suitable for you.

Page Last Updated:

28th October 2025

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Author

Content author

Scott Weaver

Medical Content Writer • Bachelor of Arts Degree

Scott is an experienced, skilled medical content writer dedicated to creating helpful and accessible health and wellbeing content for UK Meds.

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Medically Reviewed By:

Medically Reviewed By:

Alexis Missick

General Practitioner (GP) • MBChB

With over a decade of experience in the NHS and six years internationally, Alexis is a seasoned General Practitioner hailing from Turks and Caicos.

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